MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury.
RatSpinal cord injuryContusionLong-EvansFemalen = 36 rats in total; series 1 MRI 6 glibenclamide and 6 contro…Intraperitoneal loading dose plus continuous subcutaneous infusion by Alzet 2001 mini-osmotic pumpSingle intraperitoneal loading dose of 10 micrograms per kg…Loading dose at 5 minutes after trauma, with pump infusion started at the end o…
Model: Unilateral left blunt impact to the cervical spinal cord at C7 after C7 laminectomy, using a 1.01 g guide tube impactor with a 1.55 mm tip angled 5 degrees medially, driven by a 10 g weight dropped 25 mm at a velocity of 0.7 m/s, producing ipsilateral but not contralateral primary haemorrhage
Glibenclamide started 5 minutes after injury essentially abolished 24 h lesion expansion (1.2-fold versus 2.3-fold by MRI and 1.1-fold versus 2.2-fold by histology) and significantly improved unilateral BBB scores (ipsilateral median 9 versus 0, contralateral 12 versus 2, both P less than 0.001).
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