PRECLINICAL PUBLICATION · 2013

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Anti-C5a neutralising antibody, C5a receptor antagonist, and the thrombin inhibitor hirudin

PMID 24040968 ↗2013Reported benefit

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans.

RatTBIUnspecifiedSprague-DawleyMaleAdministered before injury

Model: Highly reproducible constrained blunt-force brain injury in rats

Pre-injury administration of a direct thrombin inhibitor restored platelet responsiveness to adenosine diphosphate after blunt traumatic brain injury, implicating excess thrombin in early post-injury platelet dysfunction.

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