Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats.
RatIschaemia-reperfusionRenalSprague-DawleyMaleSurgical renal vascular occlusionThree cycles of 2 minutes of ischaemia followed by 5 minute…Performed before the 45 minute ischaemic insult; the nitric oxide synthase inhi…
Model: Acute kidney injury induced by clamping the left renal artery and vein for 45 minutes followed by reperfusion, 2 weeks after contralateral nephrectomy
Ischaemic preconditioning suppressed renal sympathetic nerve activity and noradrenaline release and attenuated renal dysfunction and histological damage, an effect abolished by non-selective nitric oxide synthase inhibition.
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