Disrupted pulmonary artery cyclic guanosine monophosphate signaling in mice with hyperoxia-induced pulmonary hypertension.
MouseOtherC57BL/6Given concurrently with the 14 day hyperoxia protocol
Model: Hyperoxia-induced bronchopulmonary dysplasia-like lung injury and pulmonary hypertension: chronic hyperoxia of 75 per cent oxygen for 14 days, or acute hyperoxia of 75 per cent oxygen for 24 h followed by 13 days in room air
Sildenafil attenuated medial wall thickness and right ventricular hypertrophy and restored pulmonary artery cyclic guanosine monophosphate signalling, but did not improve mean alveolar area or vessel density.
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