Involvement of neuronal IL-1beta in acquired brain lesions in a rat model of neonatal encephalopathy.
RatIschaemia-reperfusionCerebral (MCAO/stroke)LewisMale and femalen = 5 to 6 rats per condition for the IL-1ra MRI experiment; 3…200 mg/kgFirst dose 30 min before lipopolysaccharide, approximately 4.5 h before hypoxia…
Model: Lipopolysaccharide (200 ug/kg i.p.) followed 4 h later by permanent right common carotid artery ligation plus 8% oxygen hypoxia (term-equivalent neonatal encephalopathy)
IL-1ra reduced total lesion volume from 76.7 +/- 11.7 mm3 to 17.5 +/- 2.4 mm3 at post-natal day 20 after combined lipopolysaccharide and hypoxia-ischaemia, confirming a causal role for IL-1beta.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.