Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain.
RatCrushPeripheral-nerve crushS/A albino (abstract states Sprague Dawley; full text methods state male S/A albino rats from Simonsen Laboratories)Malen = Four treatment groups (control, nerve crush, nerve crush pl…Inhalation in a hyperbaric chamber; naltrexone by intracerebroventricular osmotic minipump into the right lateral ventricle100% oxygen at 3.5 ATA for 60 min; naltrexone comparator ar…Single hyperbaric oxygen treatment 7 days after nerve crush; naltrexone minipum…
Model: Sciatic nerve crush with forceps for 10 s, repeated at 180 degrees for a further 10 s, under ketamine and xylazine anaesthesia
A single 60 min hyperbaric oxygen exposure at 3.5 ATA on day 7 restored mechanical thresholds to control levels and significantly increased the area under the curve relative to nerve crush alone. Continuous i.c.v. naltrexone completely blocked this anti-allodynic effect (F = 8.93, P = 0.0002), impl…
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