Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injury.
MouseTBIFluid percussionC57BL/6J congenic wild-type and ASIC1a-null (Asic1a-/-)Malen = pH: 9 control, 6 injured, 7 injured plus NaHCO3; fluoro-jad…Intraperitoneal2 x 10-3 moles/kg from a 200 mM stock (approximately 250 uL…Immediately after injury, or 1 h after injury
Model: Lateral fluid percussion injury (0.9 atmosphere pulse) through a craniotomy over the right parietal bone with dura intact
Bicarbonate prevented post-traumatic cortical acidosis, reduced fluoro-jade positive neurodegeneration and restored Barnes maze and contextual fear performance, with ASIC1a deletion conferring a similar but smaller protection.
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