Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- TBI
- Reported indication
- Metabolic acidosis, urinary alkalinization, and adjunct in certain resuscitation/overdose settings (systemic alkalinizer)
- First approval
- 1982
- Development stage
- Approved for metabolic acidosis; AKI prevention showed no benefit (PRESERVE)
- ChEMBL record
- CHEMBL1353 ↗
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- B1654; Baking soda; Bicarbonate of soda; Carbonic acid monosodium salt; Carbonic acid sodium salt (1:1); Monosodium carbonate; Nabic; Natrii hydrogenocarbonas; Natrum bicarbonicum; Sodium acid carbonate; Sodium bicarbonate; Sodium bicarbonate anhydrous; Thamicarb
- Note
- Not recorded
Clinical trials 4
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation
End Stage Renal Disease · Acute Renal Failure · Hemodialysis Complication
Enrolment: 451 · Results not recorded
Painless Local Anaesthesia With Bicarbonate Admixture: A Phase II, Monocentric, Double-blind, Randomized, Placebo-controlled Crossover Trial
Local Infiltration · Anesthesia
Enrolment: 48 · Results not recorded
The Effect of Acute Caffeine and Sodium Bicarbonate Supplementation on Upper and Lower Submaximal Resistance Training Performance
Nutritional Supplementation · Resistance Training
Enrolment: 12 · Results not recorded
The Effect of Sodium Bicarbonate, Saline and Black Mulberry Syrup on The Degree of Oral Mucositis in Children Receiving Chemotherapy: A Randomized Controlled Trial
Oral Mucositis · Chemotherapy Effect
Enrolment: 54 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseTBIFluid percussionC57BL/6J congenic wild-type and ASIC1a-null (Asic1a-/-)Malen = pH: 9 control, 6 injured, 7 injured plus NaHCO3; fluoro-jad…Intraperitoneal2 x 10-3 moles/kg from a 200 mM stock (approximately 250 uL…Immediately after injury, or 1 h after injury
Model: Lateral fluid percussion injury (0.9 atmosphere pulse) through a craniotomy over the right parietal bone with dura intact
Bicarbonate prevented post-traumatic cortical acidosis, reduced fluoro-jade positive neurodegeneration and restored Barnes maze and contextual fear performance, with ASIC1a deletion conferring a similar but smaller protection.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
