Evaluation of in vivo wound healing activity of Bacopa monniera on different wound model in rats.
RatWoundInbred Charles-Foster albinoEither sexOral by orogastric tube, 1 ml per 100 g body weight in 0.5% carboxymethylcellulose25 mg/kg (dose-response also tested at 12.5, 25 and 50 mg/k…Started 4 h after wounding on day 1
Model: Three cutaneous wound models: two 6 cm paravertebral full-thickness incisions; approximately 500 mm2 full-thickness dorsal excision; dead-space wound with implanted polypropylene tubes 0.5 x 2.5 cm
Bacopa extract at 25 mg/kg increased wound breaking strength (373.3 +/- 13.8 g versus 283.3 +/- 18.6 g control), shortened epithelialisation (10.3 versus 12.7 days) and raised antioxidants and connective tissue markers while lowering free radicals and myeloperoxidase, comparably to vitamin E.
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.