THERAPY DOSSIER · th-5dfc4f8fdec9

50% ethanolic extract of Bacopa monnieri whole plant

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04927338 ↗PHASE2recruiting

Phase II placebo-controlled study of BacoMind Bacopa monnieri standardised extract in Gulf War Illness

Gulf War Illness

Enrolment: 170 · Results not recorded

NCT00483964 ↗PHASE2completed

Randomised controlled trial of aqueous extracts of Bacopa monnieri and Nardostachys jatamansi in schizophrenia

Schizophrenia

Enrolment: 200 · Results not recorded

NCT06355167 ↗NAcompleted

Open-label effect of bacopaside II (Bacopa-400) on oxidative stress in healthy volunteers (BacOxy_I)

Oxidative Stress · Endothelial Dysfunction · Cardiovascular Diseases

Enrolment: 20 · Results not recorded

NCT06059131 ↗NAcompleted

Randomised double-blind effect of bacopaside II (KeenMind) on vascular oxidative stress in healthy volunteers

Oxidative Stress · Endothelial Dysfunction · Cardiovascular Diseases

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23984424 ↗2013Reported benefit

Evaluation of in vivo wound healing activity of Bacopa monniera on different wound model in rats.

RatWoundInbred Charles-Foster albinoEither sexOral by orogastric tube, 1 ml per 100 g body weight in 0.5% carboxymethylcellulose25 mg/kg (dose-response also tested at 12.5, 25 and 50 mg/k…Started 4 h after wounding on day 1

Model: Three cutaneous wound models: two 6 cm paravertebral full-thickness incisions; approximately 500 mm2 full-thickness dorsal excision; dead-space wound with implanted polypropylene tubes 0.5 x 2.5 cm

Bacopa extract at 25 mg/kg increased wound breaking strength (373.3 +/- 13.8 g versus 283.3 +/- 18.6 g control), shortened epithelialisation (10.3 versus 12.7 days) and raised antioxidants and connective tissue markers while lowering free radicals and myeloperoxidase, comparably to vitamin E.

Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.

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