Perilesional treatment with chondroitinase ABC and motor training promote functional recovery after stroke in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Long-EvansLocal intracortical injection into the ipsilesional perilesional cortexAcute and delayed treatment arms
Model: Focal cortical ischaemia of the forelimb motor cortex
Both acute and delayed chondroitinase ABC treatment restored skilled reaching performance, with associated increases in vGLUT2-positive excitatory cortical circuitry that occurred only in rats also undergoing behavioural training.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.