THERAPY DOSSIER · th-df87a5718b1a

Chondroitinase ABC, combined with motor (skilled reaching) training

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23960208 ↗2013Reported benefit

Perilesional treatment with chondroitinase ABC and motor training promote functional recovery after stroke in rats.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Long-EvansLocal intracortical injection into the ipsilesional perilesional cortexAcute and delayed treatment arms

Model: Focal cortical ischaemia of the forelimb motor cortex

Both acute and delayed chondroitinase ABC treatment restored skilled reaching performance, with associated increases in vGLUT2-positive excitatory cortical circuitry that occurred only in rats also undergoing behavioural training.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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