Postoperative opioid administration inhibits bone healing in an animal model.
RatFractureFemurSprague-Dawleyn = 50 rats in total, randomised to control or morphine, with e…Postoperatively
Model: 0.4 mm femoral osteotomy gap with operative stabilisation
Morphine significantly reduced callus strength at 8 weeks (p = 0.048) and inhibited callus resorption and remodelling, with only a 13% fall in callus volume between 4 and 8 weeks (p = 0.393) compared with a 29% fall in controls (p = 0.023).
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.