PRECLINICAL PUBLICATION · 2013

Autophagy reduces neuronal damage and promotes locomotor recovery via inhibition of apoptosis after spinal cord injury in rats.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Rapamycin (sirolimus)

PMID 23954967 ↗2013Reported benefit

Autophagy reduces neuronal damage and promotes locomotor recovery via inhibition of apoptosis after spinal cord injury in rats.

RatSpinal cord injuryUnspecifiedSprague-DawleyMale

Model: Acute thoracic spinal cord injury

Rapamycin increased LC3 and Beclin1 expression and Basso, Beattie and Bresnahan locomotor scores with up-regulated Bcl-2 and down-regulated Bax, whereas 3-methyladenine produced the opposite pattern.

Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.