Oroxylin A accelerates liver regeneration in CCl4-induced acute liver injury mice.
MouseChemical/toxinC57BL/6 wild-type and IL-1RI-/-Malen = n = 6 per group for biochemistry, histology, PCNA and ELISA…Oral60 mg/kg body weight (200 mg/ml stock in 5 g/l CMC-Na)1 h after carbon tetrachloride injection
Model: Carbon tetrachloride-induced acute liver injury, 1 ml/kg intraperitoneally (1:3 in corn oil); lethal acute liver failure model at 2.6 ml/kg (1:1 in corn oil)
Oroxylin A lowered serum ALT and AST and necrosis, raised albumin, IL-1Ra and early hepatocyte PCNA positivity, and improved survival after lethal carbon tetrachloride in wild-type mice (p = 0.0033) but not in IL-1RI-/- mice (p = 0.9141).
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