PRECLINICAL PUBLICATION · 2013

TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Mesenchymal stem cells

PMID 23921952 ↗2013Reported benefit

TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds.

MouseWoundC57BL/6Intradermal injection into the wound margins

Model: Full-thickness excisional skin wound

TSG-6 released from mesenchymal stem cells suppressed TNF-alpha release from activated macrophages and induced a shift to a low, anti-fibrotic TGF-beta1/TGF-beta3 ratio, improving wound healing and limiting fibrosis.

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