Pre-treatment with Cobra venom factor alleviates acute lung injury induced by intestinal ischemia-reperfusion in rats.
RatIschaemia-reperfusionIntestinal / mesentericSprague-Dawleymaleintravenous via tail vein24 h before the operation (pre-treatment)
Model: Intestinal ischaemia-reperfusion by superior mesenteric artery clamping for 60 min followed by 4 h reperfusion, causing remote acute lung injury
Cobra venom factor pre-treatment significantly attenuated lung histological injury, oedema and permeability, and reduced pulmonary malondialdehyde, myeloperoxidase, ICAM-1 and IL-8. Intestinal damage and raised plasma diamine oxidase were also alleviated.
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