Effects of low-dose methotrexate in spinal cord injury in rats.
RatSpinal cord injuryCompressionWistar albinon = 37 rats in totalintraperitonealafter clip compression
Model: Thoracic laminectomy followed by temporary aneurysm clip compression spinal cord injury
Low-dose methotrexate reduced lipid peroxidation in the subacute stage only. It did not improve histopathological grade at either stage and neither methotrexate nor methylprednisolone reduced myeloperoxidase activity.
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