Intramuscular transplantation and survival of freshly isolated bone marrow cells following skeletal muscle ischemia-reperfusion injury.
MouseIschaemia-reperfusionLimb / skeletal muscletransgenic (bioluminescent reporter) miceintramuscular injection0, 2, 7 and 14 days after injury for survival studies; 2 days after injury for…
Model: Acute skeletal muscle ischaemia-reperfusion injury of the hind limb
Lineage-negative bone marrow cells survived after intramuscular transplantation regardless of delivery timing, but did not improve maximal isometric torque. Both saline and cell-injected muscles showed an increased twitch-tetanus ratio, suggesting injection-related damage.
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