THERAPY DOSSIER · th-82b90a753784

Lineage-negative bone marrow cells isolated by magnetic-activated cell sorting

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23883899 ↗2013No effect reported

Intramuscular transplantation and survival of freshly isolated bone marrow cells following skeletal muscle ischemia-reperfusion injury.

MouseIschaemia-reperfusionLimb / skeletal muscletransgenic (bioluminescent reporter) miceintramuscular injection0, 2, 7 and 14 days after injury for survival studies; 2 days after injury for…

Model: Acute skeletal muscle ischaemia-reperfusion injury of the hind limb

Lineage-negative bone marrow cells survived after intramuscular transplantation regardless of delivery timing, but did not improve maximal isometric torque. Both saline and cell-injected muscles showed an increased twitch-tetanus ratio, suggesting injection-related damage.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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