Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats.
RatOtherSprague-Dawleymalen = n = 8 to 9 per group for the tolerance-inducing paradigm; n…subcutaneous, intraplantar, and intraperitoneal for antagonistsSystemic loperamide 1.5 mg/kg subcutaneously for testing; t…days 5 to 8 after spinal nerve ligation, when hypersensitivity is at a stable m…
Model: L5 spinal nerve ligation producing neuropathic mechanical hypersensitivity
A single systemic dose of loperamide raised the ipsilateral paw withdrawal threshold at 30 min, but this antiallodynic effect was significantly diminished by day 8 after repeated dosing, with dose-dependent tolerance at 1.5, 3.0 and 6.0 mg/kg but not 0.75 mg/kg. Tolerance also developed to intrapla…
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