Efficacy of loperamide in Clostridium difficile colitis and antibiotic-associated diarrhoea of unknown cause
Antibiotic-Associated Diarrhea · Clostridium Difficile
Enrolment: 120 · Results not recorded
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Drug · Mu opioid receptor agonist (AGONIST; direct_interaction true, disease_efficacy true; mec_id 706)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Antibiotic-Associated Diarrhea · Clostridium Difficile
Enrolment: 120 · Results not recorded
Colorectal Cancer Metastatic
Enrolment: 76 · Results not recorded
Low Anterior Resection Syndrome · Rectal Carcinoma
Enrolment: 80 · Results not recorded
Low Anterior Resection Syndrome
Enrolment: 212 · Results not recorded
Healthy
Enrolment: 26 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: L5 spinal nerve ligation producing neuropathic mechanical hypersensitivity
A single systemic dose of loperamide raised the ipsilateral paw withdrawal threshold at 30 min, but this antiallodynic effect was significantly diminished by day 8 after repeated dosing, with dose-dependent tolerance at 1.5, 3.0 and 6.0 mg/kg but not 0.75 mg/kg. Tolerance also developed to intrapla…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.