Sodium butyrate protects against severe burn-induced remote acute lung injury in rats.
RatBurnScaldSprague-Dawleyfemalen = 48 burned rats randomised to burn (n = 24) and burn plus so…intraperitoneal400 mg/kg, diluted 1:150 in lactated Ringer's solutionfirst dose at 6 h after burn
Model: Full-thickness third-degree dermal burn over 30 per cent total body surface area by immersion of template-exposed dorsal skin in 98 degrees Celsius water for 12 s under pentobarbital anaesthesia, causing remote acute lung injury
Sodium butyrate significantly suppressed burn-induced increases in bronchoalveolar lavage and serum TNF-alpha and IL-8, lung wet to dry ratio, histological injury score, myeloperoxidase activity and pulmonary HMGB1 expression, with most differences significant at 24 and 48 h. Lung wet to dry ratio…
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