Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats.
RatOtherSprague-DawleyMale5 ml/kgBeginning 1 day after unilateral ureteral obstruction
Model: Unilateral ureteral obstruction by ligation of the left ureter; kidneys harvested 10 days after obstruction
Hydrogen-rich saline significantly reduced renal injury score, apoptosis index, interstitial fibrosis and macrophage infiltration compared with obstructed controls. It also lowered MDA and improved SOD activity, indicating reduced oxidative stress.
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