A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin.
RatSpinal cord injuryContusionAthymic nudeIntraspinal cell transplantation; decorin by mini-osmotic pumpDecorin from 7 days (sub-acute) or 1 month (chronic) after injury; cells transp…
Model: Contusive spinal cord injury at T9, treated in sub-acute (7 day) and chronic (1 month) regimes
Human mesenchymal precursor cell transplantation significantly improved functional recovery, tissue sparing and cyst volume reduction in both sub-acute and chronic injury. Adding decorin did not improve these outcomes beyond cells alone, although decorin infusion alone improved tissue sparing, redu…
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