THERAPY DOSSIER · th-a119b12abc98

Human Stro-1 positive mesenchymal precursor cells with or without recombinant human decorin (core and proteoglycan isoforms)

Biologic · Cell therapy (Stro-1+ mesenchymal precursor cells +/- decorin); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (Stro-1+ mesenchymal precursor cells +/- decorin); not a ChEMBL entity
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02412735 ↗PHASE3completed

Rexlemestrocel-L (mesenchymal precursor cells) Alone or With HA in Chronic Low Back Pain

Degenerative Disc Disease

Enrolment: 404 · Results not recorded

NCT01290367 ↗PHASE2completed

Adult Mesenchymal Precursor Cells (MPCs) Combined With Hyaluronan in Chronic Discogenic Lumbar Back Pain

Degenerative Disc Disease

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23867131 ↗2013Mixed findings

A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin.

RatSpinal cord injuryContusionAthymic nudeIntraspinal cell transplantation; decorin by mini-osmotic pumpDecorin from 7 days (sub-acute) or 1 month (chronic) after injury; cells transp…

Model: Contusive spinal cord injury at T9, treated in sub-acute (7 day) and chronic (1 month) regimes

Human mesenchymal precursor cell transplantation significantly improved functional recovery, tissue sparing and cyst volume reduction in both sub-acute and chronic injury. Adding decorin did not improve these outcomes beyond cells alone, although decorin infusion alone improved tissue sparing, redu…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

Loading the evidence…