Combination of chondroitinase ABC and AAV-NT3 promotes neural plasticity at descending spinal pathways after thoracic contusion in rats.
RatSpinal cord injuryContusionSprague-DawleyFemale
Model: Chronic thoracic T10 contusion spinal cord injury
Disrupted dorsal corticospinal axons spontaneously formed weak detour synaptic connections with lumbar motoneurons through spared ventrolateral white matter. Chondroitinase ABC combined with AAV-NT3 strengthened these connections, induced additional detour pathways to dorsomedial interneurons, incr…
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