THERAPY DOSSIER · th-b23297fefd8c

Chondroitinase ABC combined with adeno-associated viral vector mediated neurotrophin-3

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23864374 ↗2013Reported benefit

Combination of chondroitinase ABC and AAV-NT3 promotes neural plasticity at descending spinal pathways after thoracic contusion in rats.

RatSpinal cord injuryContusionSprague-DawleyFemale

Model: Chronic thoracic T10 contusion spinal cord injury

Disrupted dorsal corticospinal axons spontaneously formed weak detour synaptic connections with lumbar motoneurons through spared ventrolateral white matter. Chondroitinase ABC combined with AAV-NT3 strengthened these connections, induced additional detour pathways to dorsomedial interneurons, incr…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

Loading the evidence…