Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney.
MouseChemical/toxinSwissMaleOralPre-treatment for 7 days before carbon tetrachloride challenge on day 8
Model: Carbon tetrachloride 10 mmol/kg intraperitoneally on day 8, with assessment 24 h later
Carbon tetrachloride raised malondialdehyde, depressed antioxidant enzymes and glutathione, and produced glomerular and tubular degeneration, collagen deposition and strong TGF-beta1 expression. Naringenin pre-treatment returned biochemical markers to control values, with histological and ultrastru…
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