Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats.
RatTBIPenetrating / ballisticSprague-DawleyMaleEthosuximide 12.5 to 187.5 mg/kg and phenytoin 5 to 30 mg/k…
Model: Penetrating ballistic-like brain injury producing spontaneous nonconvulsive seizures, detected by continuous EEG monitoring for 72 h after injury
Both drugs dose-dependently attenuated nonconvulsive seizures, with the two highest doses of each reducing incidence from 69 to 73 per cent in vehicle animals to 13 to 40 per cent and frequency from 9 to 10 episodes per rat to 1.8 to 6.2. Seizure onset was delayed, with fewer than 20 per cent of tr…
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