Effectiveness of ethosuximide in peripheral neuropathic pain
Neuropathic Traumatic Pain · Pain NRS >= 4 · Peripheral Neuropathic Pain · Neuropathic Pain Diagnostic Questionnaire (DN4) >= 4
Enrolment: 114 · Results not recorded
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Drug · Voltage-gated T-type calcium channel blocker
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Neuropathic Traumatic Pain · Pain NRS >= 4 · Peripheral Neuropathic Pain · Neuropathic Pain Diagnostic Questionnaire (DN4) >= 4
Enrolment: 114 · Results not recorded
IBS - Irritable Bowel Syndrome
Enrolment: 60 · Results not recorded
Childhood Absence Epilepsy · Petit Mal Epilepsy · Epilepsy · Seizures
Enrolment: 453 · Results not recorded
Complex Regional Pain Syndromes
Enrolment: 4 · Results not recorded
Cancer · Peripheral Neuropathy
Enrolment: 15 · Results not recorded
Irritable Bowel Syndrome
Enrolment: 162 · Results not recorded
Headache, Migraine
Enrolment: 5 · Results not recorded
Depressive Disorder, Treatment-Resistant
Enrolment: 16 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Penetrating ballistic-like brain injury producing spontaneous nonconvulsive seizures, detected by continuous EEG monitoring for 72 h after injury
Both drugs dose-dependently attenuated nonconvulsive seizures, with the two highest doses of each reducing incidence from 69 to 73 per cent in vehicle animals to 13 to 40 per cent and frequency from 9 to 10 episodes per rat to 1.8 to 6.2. Seizure onset was delayed, with fewer than 20 per cent of tr…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.