TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
MouseOtherC57BL/6 wild type, Trpm8 knockout, Trpa1 knockout, Trpv1 knockout and double knockoutsMalen = Rotarod n=5 to 7 per group; acrolein nocifensive n=8 to 12…Oral gavage, intraperitoneal, intraplantar and topicalL-menthol 10 mg/kg orally, 10 or 20 mg/kg intraperitoneally…Pre-treatment or co-administration; oral and intraperitoneal menthol 30 min bef…
Model: No trauma model. Acute and inflammatory pain challenges including hot plate at 52 and 55 degrees C, radiant heat tail flick, 0.6 per cent acetic acid writhing, intraplantar capsaicin and acrolein, and complete Freund's adjuvant 20 microlitre intraplantar
L-menthol produced analgesia across every model tested, roughly doubling hot plate latency and reducing capsaicin, acrolein, acetic acid and complete Freund's adjuvant evoked responses, with eucalyptol and WS-12 reproducing the effect. All analgesia was abolished in Trpm8 knockout mice and by AMG28…
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