THERAPY DOSSIER · th-3a1b761af4f3

L-menthol, with eucalyptol, the selective TRPM8 agonist WS-12, the TRPM8 inhibitor AMG2850, acetaminophen and naloxone

Nutraceutical · TRPM8 opener (mec_id 942) and TRPA1 opener (mec_id 1031); both OPENER, direct_interaction true, disease_efficacy true

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: TRPM8 opener (mec_id 942) and TRPA1 opener (mec_id 1031); both OPENER, direct_interaction true, disease_efficacy true
Target: CHEMBL1075319 (TRPM8); CHEMBL6007 (TRPA1)
Injury models: Other
Reported indication: Not recorded
First approval: 2008
Development stage: Not recorded
ChEMBL record: CHEMBL256087 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Menthol; Racementhol; dl-menthol; Levomenthol (CHEMBL470670, L-enantiomer, max_phase 3); L-menthol; Halls; Dermacool
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04593836 ↗PHASE3unknown

Antiperistaltic effect and safety of L-menthol vs placebo for upper GI endoscopy in the elderly

Upper Gastrointestinal Endoscopy

Enrolment: 60 · Results not recorded

NCT07398287 ↗PHASE2recruiting

Effect of L-menthol on breathlessness and exercise capacity in interstitial lung disease: randomised crossover trial

Interstitial Lung Disease

Enrolment: 20 · Results not recorded

NCT07500974 ↗PHASE2not yet recruiting

Effect of L-menthol on breathlessness and exercise capacity in asthma: randomised crossover trial

Asthma

Enrolment: 20 · Results not recorded

NCT03132142 ↗NAunknown

Temporal profile of nociceptive desensitisation by 8% topical capsaicin and functional independence of TRPA1- and TRPV1-expressing afferents (L-menthol arm)

Pain · Pruritus · Neuropathic Pain

Enrolment: 22 · Results not recorded

NCT05785026 ↗NArecruiting

Effectiveness and mechanisms of menthol inhalation for relief of dyspnoea in health and COPD

Dyspnea · Chronic Obstructive Pulmonary Disease

Enrolment: 120 · Results not recorded

NCT07745049 ↗NAcompleted

Acute effects of menthol gargle and buccal film on anaerobic capacity and respiratory parameters

Menthol

Enrolment: 16 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23820004 ↗2013Reported benefit

TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.

MouseOtherC57BL/6 wild type, Trpm8 knockout, Trpa1 knockout, Trpv1 knockout and double knockoutsMalen = Rotarod n=5 to 7 per group; acrolein nocifensive n=8 to 12…Oral gavage, intraperitoneal, intraplantar and topicalL-menthol 10 mg/kg orally, 10 or 20 mg/kg intraperitoneally…Pre-treatment or co-administration; oral and intraperitoneal menthol 30 min bef…

Model: No trauma model. Acute and inflammatory pain challenges including hot plate at 52 and 55 degrees C, radiant heat tail flick, 0.6 per cent acetic acid writhing, intraplantar capsaicin and acrolein, and complete Freund's adjuvant 20 microlitre intraplantar

L-menthol produced analgesia across every model tested, roughly doubling hot plate latency and reducing capsaicin, acrolein, acetic acid and complete Freund's adjuvant evoked responses, with eucalyptol and WS-12 reproducing the effect. All analgesia was abolished in Trpm8 knockout mice and by AMG28…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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