Quercetin inhibits radiation-induced skin fibrosis.
MouseRadiationC3H/HeNFemalen = 8 mice per group for leg contraction; 3 mice per group per…Oral, dietary chow ad libitum1 per cent quercetin by dry weight in rodent chow in vivo;…Chow started 1 week before irradiation and continued for the study duration; in…
Model: Single fraction X-irradiation of the right hind leg with the body lead shielded, 35 Gy at 300 kVp and 1.9 Gy/min; separate SCC-VII tumour arm irradiated at 10 Gy; in vitro clonogenic assays at 2 Gy
Dietary 1 per cent quercetin significantly reduced radiation-induced hind limb contracture at 120 and 150 days and lowered dermal collagen and TGF-beta in irradiated skin, without affecting chow intake, body weight or the acute skin reaction. Quercetin gave no radioprotection of fibroblasts in clon…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.