Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice.
MouseRadiationCD2F1Malen = n=16 per group in the combined injury cell transfusion expe…Alpha-tocopherol succinate and AMD3100 subcutaneous to donors; cells given via the retro-orbital sinus, described in the abstract as intravenous transfusionAlpha-tocopherol succinate 400 mg/kg, AMD3100 5 mg/kg, tran…Recipients transfused 24 h after irradiation, with wounding within 1 h after ir…
Model: Bilateral cobalt-60 total body irradiation at 0.6 Gy/min, doses of 8, 9.2, 11, 11.5, 12.0, 12.5, 13.0 and 14.0 Gy; combined injury adds a non-lethal full thickness dorsal skin wound made with a 9/16 inch arch punch within 1 h after irradiation
Transfusion of mobilised peripheral blood mononuclear cells 24 h after irradiation significantly improved survival at 11.5, 12.0 and 12.5 Gy on day 10 and at 11.5 and 12.0 Gy on days 15 and 30, and both mobilised cells and alpha-tocopherol succinate alone improved survival after 9.2 Gy plus woundin…
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