What is the best treatment to decrease pro-inflammatory cytokine release in acute skeletal muscle injury induced by trauma in rats: low-level laser therapy, diclofenac, or cryotherapy?
RatCrushLimb / muscle crushWistarMaleTranscutaneous laser irradiation; topical diclofenac; topical cryotherapy904 nm, superpulsed, 700 Hz, 60 mW mean output power, 1.67…1 hour after trauma
Model: Single controlled trauma to the tibialis anterior muscle
Low-level laser therapy at the 1 J dose significantly decreased IL-1 beta, IL-6 and TNF-alpha compared with the non-treated injured group and with the diclofenac and cryotherapy groups. Diclofenac and cryotherapy did not reduce pro-inflammatory cytokine levels relative to the non-treated injured gr…
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