Human umbilical-cord-blood mononucleated cells enhance the survival of lethally irradiated mice: dosage and the window of time.
MouseRadiationA/JFemalen = 66 mice in six groups: sham 6, irradiation alone 9, 1 x 10^…Retro-orbital injection for the cord blood cells; antibiotic given in drinking water1 x 10^8 or 2 x 10^8 human umbilical cord blood mononuclear…Cord blood cells from 24 to 52 h after irradiation; Levaquin started 4 h after…
Model: Acute lethal total body irradiation with 9 to 10 Gy of caesium-137 gamma rays delivered at 1 Gy/min in a ventilated irradiator
More than 93 per cent of mice given 2 x 10^8 cord blood mononucleated cells plus Levaquin survived to 50 days, significantly better than irradiation alone (P less than 0.01). The 1 x 10^8 dose with Levaquin gave 66 per cent survival (P = 0.08), Levaquin alone 58 per cent and cord blood alone 36 per…
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