Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury.
RatSpinal cord injuryHemisection / partialMaleAnti-Nogo-A antibody applied acutely after injury, chondroitinase ABC delayed t…
Model: Cervical partial spinal cord injury in rats, with recovery of forelimb function related to the extent of the ipsilateral lesion
Either single treatment with rehabilitation produced functional recovery of similar magnitude, while the combination was more effective and produced greater increases in sprouting and axon regeneration. Anti-Nogo-A stimulated growth of axons larger than 3 micrometres in diameter, whereas chondroiti…
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