THERAPY DOSSIER · th-6b42da2986ce

Anti-Nogo-A antibody combined with chondroitinase ABC and rehabilitation

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00406016 ↗Injury indicationPHASE1completed

Continuous intrathecal ATI355 (anti-Nogo-A antibody) infusion and repeated intrathecal bolus injections in acute spinal cord injury

Acute Spinal Cord Injury

Enrolment: 52 · Results not recorded

NCT01753076 ↗PHASE2completed

NOG112264: ozanezumab (GSK1223249) versus placebo in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis

Enrolment: 304 · Results not recorded

NCT01435993 ↗PHASE1terminated

GSK1223249 (ozanezumab) single and repeat ascending dose in relapsing forms of multiple sclerosis

Multiple Sclerosis, Relapsing-Remitting

Enrolment: 3 · Results not recorded

NCT00875446 ↗PHASE1completed

Single and repeat dose escalation of GSK1223249 (ozanezumab) in ALS patients

Amyotrophic Lateral Sclerosis

Enrolment: 76 · Results not recorded

NCT01424423 ↗PHASE1terminated

Single ascending dose of intravenous GSK1223249 (ozanezumab) in relapsing forms of multiple sclerosis

Multiple Sclerosis

Enrolment: 3 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23790207 ↗2013Reported benefit

Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury.

RatSpinal cord injuryHemisection / partialMaleAnti-Nogo-A antibody applied acutely after injury, chondroitinase ABC delayed t…

Model: Cervical partial spinal cord injury in rats, with recovery of forelimb function related to the extent of the ipsilateral lesion

Either single treatment with rehabilitation produced functional recovery of similar magnitude, while the combination was more effective and produced greater increases in sprouting and axon regeneration. Anti-Nogo-A stimulated growth of axons larger than 3 micrometres in diameter, whereas chondroiti…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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