Does urinary trypsin inhibitor have a role in acute lung injury induced by pulmonary contusion: a basic research in a model of rats.
RatCrushOther / unspecifiedSprague-DawleyMale20 000 U/kg (low dose) or 50 000 U/kg (high dose)Given after contusion, with assessment at 12 h
Model: Moderate pulmonary contusion from blunt chest trauma causing acute lung injury
High-dose urinary trypsin inhibitor significantly reduced bronchoalveolar lavage neutrophil count and TNF-alpha and lung malondialdehyde, and raised superoxide dismutase and catalase activity (P less than 0.05), with a dose-dependent trend. Bronchoalveolar albumin fell without significance, and the…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.