Acute toxicity and gastroprotective role of M. pruriens in ethanol-induced gastric mucosal injuries in rats.
RatChemical/toxinSprague DawleyMale and female in the acute toxicity study; sex not stated for the gastric ulcer studyn = 48 rats in 8 groups of 6 for the gastric ulcer study, and 3…Oral, 5 mL/kg suspended in 0.5 per cent carboxymethylcellulose62.5, 125, 250 and 500 mg/kg in the experimental groups, 50…Single pretreatment 1 h before oral absolute ethanol, with sacrifice 1 h after…
Model: Gastric mucosal injury induced by oral administration of absolute ethanol after a 24 h fast
The extract dose-dependently reduced ulcer area, submucosal oedema and leukocyte infiltration, increased gastric wall mucus, periodic acid Schiff staining and mucosal protein, raised prostaglandin E2, superoxide dismutase, catalase and glutathione, lowered malondialdehyde, upregulated Hsp70 and dow…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.