THERAPY DOSSIER · th-89c8fc975b8d

Mucuna pruriens leaf ethanolic extract

Nutraceutical · Botanical extract (Mucuna pruriens); not a discrete ChEMBL entity

Evidence & regulatory context

Mechanism: Botanical extract (Mucuna pruriens); not a discrete ChEMBL entity
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02680977 ↗PHASE2completed

Mucuna Pruriens Therapy in Parkinson's Disease (double-blind crossover)

Parkinson's Disease

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23781513 ↗2013Reported benefit

Acute toxicity and gastroprotective role of M. pruriens in ethanol-induced gastric mucosal injuries in rats.

RatChemical/toxinSprague DawleyMale and female in the acute toxicity study; sex not stated for the gastric ulcer studyn = 48 rats in 8 groups of 6 for the gastric ulcer study, and 3…Oral, 5 mL/kg suspended in 0.5 per cent carboxymethylcellulose62.5, 125, 250 and 500 mg/kg in the experimental groups, 50…Single pretreatment 1 h before oral absolute ethanol, with sacrifice 1 h after…

Model: Gastric mucosal injury induced by oral administration of absolute ethanol after a 24 h fast

The extract dose-dependently reduced ulcer area, submucosal oedema and leukocyte infiltration, increased gastric wall mucus, periodic acid Schiff staining and mucosal protein, raised prostaglandin E2, superoxide dismutase, catalase and glutathione, lowered malondialdehyde, upregulated Hsp70 and dow…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…