Glycyrrhizin represses total parenteral nutrition-associated acute liver injury in rats by suppressing endoplasmic reticulum stress.
RatChemical/toxinSprague-DawleyMalen = 6 per groupIntravenous bolus1, 3 or 10 mg/kg in 1 mL normal salinePretreatment, immediately before starting the total parenteral nutrition infusi…
Model: Total parenteral nutrition-associated acute liver injury induced by intravenous Kabiven infusion at 20 mL/kg/h for 3 h under urethane anaesthesia (1 g/kg intraperitoneally)
Glycyrrhizin pretreatment dose-dependently normalised AST, ALT, total bilirubin and triglyceride, restored normal hepatocyte counts (zone 1: 310 +/- 18 at 10 mg/kg vs 204 +/- 14 with total parenteral nutrition alone and 408 +/- 12 in controls), reduced cleaved caspase-3 positive hepatocytes and low…
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