Effects of mesenchymal stem cell therapy on the time course of pulmonary remodeling depend on the etiology of lung injury in mice.
MouseEndotoxin/LPSC57BL/6Female and malen = 143 female and 24 male mice in totalIntravenous1 x 10 cells in 0.05 mL saline per mouse as printed; expone…1 day after lipopolysaccharide administration
Model: Acute lung injury induced by Escherichia coli lipopolysaccharide given intratracheally (2 mg/kg in 0.05 mL saline, pulmonary injury) or intraperitoneally (20 mg/kg in 0.5 mL saline, extrapulmonary injury), with controls receiving equivalent volumes of saline
Mesenchymal stem cells reduced lung elastance, alveolar collapse and inflammation at days 2 and 7 in both models, and reduced collagen deposition only in pulmonary acute lung injury, where matrix metalloproteinase-8 increased and tissue inhibitor of metalloproteinase-1 decreased
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