Optimal time window of myelotomy in rats with acute traumatic spinal cord injury: a preliminary study.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 65 rats across five groupsSurgical8, 24 or 48 h after injury
Model: Contusion spinal cord injury produced with a New York University impactor after laminectomy
Myelotomy at 8 or 24 h improved Basso, Beattie and Bresnahan scores versus contusion alone (P < 0.008) with less benefit at 48 h (P = 0.023); all myelotomy groups had higher inclined plane angles (P < 0.005) and greater spared white matter area, and the 24 h group showed higher intra-axonal and mye…
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