THERAPY DOSSIER · th-0f349725934e

Microsurgical myelotomy

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23752264 ↗2013Reported benefit

Optimal time window of myelotomy in rats with acute traumatic spinal cord injury: a preliminary study.

RatSpinal cord injuryContusionSprague-DawleyFemalen = 65 rats across five groupsSurgical8, 24 or 48 h after injury

Model: Contusion spinal cord injury produced with a New York University impactor after laminectomy

Myelotomy at 8 or 24 h improved Basso, Beattie and Bresnahan scores versus contusion alone (P < 0.008) with less benefit at 48 h (P = 0.023); all myelotomy groups had higher inclined plane angles (P < 0.005) and greater spared white matter area, and the 24 h group showed higher intra-axonal and mye…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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