Redox markers and inflammation are differentially affected by atorvastatin, pravastatin or simvastatin administered before endotoxin-induced acute lung injury.
MouseEndotoxin/LPSC57BL/6Malen = Five groups; number per group not statedIntraperitonealAtorvastatin 10 mg/kg/day, pravastatin 5 mg/kg/day, simvast…Administered before LPS challenge
Model: Endotoxin-induced acute lung injury by intraperitoneal LPS 10 mg/kg
Atorvastatin and pravastatin showed anti-inflammatory and antioxidant activity whereas simvastatin did not; all three statins reduced lipid peroxidation and TNF-alpha.
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