Preinjury alcohol exposure attenuates the neuroinflammatory response to traumatic brain injury.
MouseTBIWeight-drop / impact-accelerationC57BL/6Malen = n = 5 per sham group and n = 8 per traumatic brain injury g…Intragastric lavageSingle 5 g/kg dose of 32% (vol/vol) ethanol in water1 h before injury
Model: Blunt traumatic brain injury by weight-drop device under 2% isoflurane
Pre-injury ethanol reduced local and systemic proinflammatory cytokine responses but slowed neurological recovery and significantly increased post-traumatic apnoea time.
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