Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation.
RatSpinal cord injuryCompressionSprague-DawleyFemalen = 42 animals total: 14 grafted, 10 vehicle, 8 non-injected in…Intraspinal (intraparenchymal) injection, 33 gauge needle, 0.80 mm depthTwelve intraspinal injections at 20,000 cells per microlitr…Three days after injury
Model: L3 spinal compression injury via Th13 laminectomy with a 35 g acrylic rod (2.9 mm diameter) applied for 15 min
Grafting improved lower extremity paw placement, spasticity and thermal and tactile thresholds, with no significant differences in BBB score, motor evoked potentials, other CatWalk parameters or ladder climbing.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.