THERAPY DOSSIER · th-b9c590702eb3

Human fetal spinal cord-derived neural stem cells (NSI-566RSC, HSSC)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03296618 ↗PHASE1unknown

Phase I Clinical Study of Intracerebral Transplantation of Neural Stem Cells for the Treatment of Ischemic Stroke

Ischemic Motor Stroke, Chronic

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23710605 ↗2013Mixed findings

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation.

RatSpinal cord injuryCompressionSprague-DawleyFemalen = 42 animals total: 14 grafted, 10 vehicle, 8 non-injected in…Intraspinal (intraparenchymal) injection, 33 gauge needle, 0.80 mm depthTwelve intraspinal injections at 20,000 cells per microlitr…Three days after injury

Model: L3 spinal compression injury via Th13 laminectomy with a 35 g acrylic rod (2.9 mm diameter) applied for 15 min

Grafting improved lower extremity paw placement, spasticity and thermal and tactile thresholds, with no significant differences in BBB score, motor evoked potentials, other CatWalk parameters or ladder climbing.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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